Innovent Showcases Preclinical Data of its First-in-Class IL-6 x TL1A Bispecific Antibody at ACR Convergence 2026

PALO ALTO, Calif. and SUZHOU, China, Nov. 12, 2026 — Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures, and commercializes high-quality medicines for the treatment of oncology, autoimmune, cardiovascular, and metabolic, ophthalmology and other major disease areas, presented for the first time the preclinical data of IAR177 as a poster in ACR Convergence 2026 held in Orlando, Florida. By simultaneously targeting two distinct pathways, IAR177 is designed to break the existing therapeutic ceiling of various rheumatic diseases. IAR177 is a thoughtfully designed molecule with the following features:

• Unique Epitope of anti-TL1A prevents immune complex formation and alleviates immunogenicity risk.
• Potent blockade of IL6 of different states maximizes signaling inhibition.
• Superior Efficacy: In-vitro and in-vivo model of rheumatoid arthritis demonstrate better response of IAR177 than single-target blockade, underscoring the therapeutic potential in suboptimal responders and refractory patients.
• Excellent Developability and PK profile support high-concentration formulation for infrequent and subcutaneous dosing.

Dr. Huizhong Xiong, Vice President of Innovent Academy: 
"Rheumatic diseases are complex systemic illnesses that can cause extensive damage with limited efficacy. IAR177 is a rationally-designed and thoroughly optimized IL-6 x TL1A bispecific antibody. It can achieve higher efficacy and potentially disease modification and remission by profoundly suppressing two disease drivers through different stages and tissues of the disease. We hope it will provide patients with the next-generation of more effective treatment option, and become an integral part of our expanding rheumatology pipeline." 

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SOURCE Innovent Biologics